Sure, Nancy Reagan told Americans to "Just Say No."

Cocaine
Sure, Nancy Reagan told Americans to "Just Say No." But the U.S. government estimates that between 1980 and 1985, the number of Americans taking extra-long trips to the bathroom more than doubled - from 10 million to 22 million. Apparently, cocaine use began its upsurge in the mid-1970s, after the smokeable form, freebase, hit the market. Ironically, freebase wasn’t technically cocaine. Rather, it was an alkaloid made by reverse-engineering pure cocaine powder - a nifty little transformation American chemists decided to try in 1974 after mistranslating the Spanish word basé. The chemists thought they were dealing with a base substance, not realizing that basé referred to a cheap paste byproduct of cocaine commonly smoked in Peru.